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a- Glucosidase inhibitors extracted from the roots of Polygonum multiflorum Thunb
- Yang, Jian-Bo, Tian, Jin-Ying, Dai, Zhong, Ye, Fei, Ma, Shuang-Cheng, Wang, Ai-Guo
- Fitoterapia 2017 v.117 pp. 65-70
- Reynoutria multiflora, ethanol, glucosides, inhibitory concentration 50, mass spectrometry, nuclear magnetic resonance spectroscopy, roots
- A novel stilbene glucoside, polygonumnolide D (1), and a novel dianthrone glycoside, polygonumnolide E (2), were isolated from a 70% EtOH extract of the dried roots of Polygonum multiflorum Thunb., together with six known compounds (3–8). Their structures were elucidated by 1D and 2D NMR as well as mass spectroscopy data. The isolated compounds were evaluated for their a-glucosidase inhibitory activities in vitro. Compounds 1, 2 and 5 showed the inhibitory activity against a-glucosidase with the IC50 values of 2.4, 2.7 and 0.3μM, respectively.