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Sequence-Controlled Delivery of Peptides from Hierarchically Structured Nanomaterials

Author:
He, Carl Wei, Parowatkin, Maria, Mailänder, Volker, Flechtner-Mors, Marion, Ziener, Ulrich, Landfester, Katharina, Crespy, Daniel
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.4 pp. 3885-3894
ISSN:
1944-8252
Subject:
drugs, endocytosis, human cell lines, models, nanocarriers, nanofibers, nanoparticles, peptides, polymers
Abstract:
Peptide drugs delivered orally need to be protected from degradation for achieving their functions. To fulfill the complicated task of oral drug delivery, we present a hierarchically structured drug-delivery system that can undertake structural changes, so multiple functions can be triggered by a sequence of stimuli. Such hierarchical system is achieved in a nanoparticle-in-nanofiber configuration, in which both the nanofibers and the nanoparticles are pH-responsive and biocompatible. A model peptide is efficiently encapsulated under mild condition, and the nanocarriers are further electrospun with a pH-responsive mucoadhesive polymer. The nanoparticles are released from the nanofibers, and thereafter the peptides are released from the nanoparticles in a pH-responsive manner. The nanoparticles are compatible with caco-2 cells, and the endocytosis of the nanoparticles is described in detail.
Agid:
5621490