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Flavonoids from the roots of Artocarpus heterophyllus

Author:
Yuan, Wen-Jun, Yuan, Jin-Bin, Peng, Jia-Bing, Ding, Yuan-Qing, Zhu, Ji-Xiao, Ren, Gang
Source:
Fitoterapia 2017 v.117 pp. 133-137
ISSN:
0367-326X
Subject:
Artocarpus heterophyllus, cathepsin K, flavonoids, inhibitory concentration 50, nuclear magnetic resonance spectroscopy, roots
Abstract:
Four new flavonoids, artoheteroids A-D (1–4), together with six known ones (5–10), were isolated from the roots of Artocarpus heterophyllus. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR, UV, IR, CD, and HR-ESI-MS. All isolated compounds were screened for their inhibitory abilities against cathepsin K (CatK). Among them, compounds 1–2, 4–6, and 10 were found to have suppression capabilities against CatK with IC50 values ranging from 1.4 to 93.9μM.
Agid:
5627276