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Reactive Oxygen Species and Glutathione Dual Redox-Responsive Supramolecular Assemblies with Controllable Release Capability

Kang, Yang, Ju, Xin, Ding, Li-Sheng, Zhang, Sheng, Li, Bang-Jing
ACS Applied Materials & Interfaces 2017 v.9 no.5 pp. 4475-4484
adverse effects, beta-cyclodextrin, biocompatibility, cell proliferation, cytotoxicity, drug delivery systems, drugs, glutathione, micelles, nanoparticles, neoplasm cells, neoplasms, polyethylene glycol, reactive oxygen species
A dual redox and biorelevant triggered supramolecular system is developed through noncovalent supramolecular inclusion interactions between the ferrocene (Fc) modified on camptothecin (CPT) and β-cyclodextrin (β-CD) at the end of methoxy polyethylene glycol (mPEG). With these two segments, a stable noncovalent supramolecular structure, i.e., mPEG-β-CD/Fc-CPT, can be formed, and then self-assembled into micellar structures in water. Interestingly, these supramolecular micelles showed uniform sphere structure, high and constant drug loading content, hyper-fast redox-responsive drug release, and exhibited equal cellular proliferation inhibition toward A549 cancer cells. The cytotoxicity evaluation of mPEG-β-CD also indicated good biocompatibility. In vivo results revealed the mPEG-β-CD/Fc-CPT nanoparticles had higher in vivo efficacy without side effects. It is anticipated this supramolecular complex may serve as a new kind of promising alternative for drug delivery systems.