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A Smart, Photocontrollable Drug Release Nanosystem for Multifunctional Synergistic Cancer Therapy
- Yi, Yi, Wang, Huijing, Wang, Xuewei, Liu, Qiaoling, Ye, Mao, Tan, Weihong
- ACS Applied Materials & Interfaces 2017 v.9 no.7 pp. 5847-5854
- DNA assembly, doxorubicin, gold, irradiation, nanorods, neoplasms, photochemotherapy, photosensitizing agents, porphyrins, synergism
- Multifunctional synergistic therapy holds promise in biomedical studies and clinical practice. However, strategies aimed at easily integrating the components of such multimodal therapies are needed. Therefore, we herein report a smart drug release nanosystem able to perform photodynamic therapy, photothermal therapy and chemotherapy in a photocontrollable manner. Doxorubicin (DOX), a chemotherapy drug, and 5, 10, 15, 20-tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP4), a photosensitizer, were physically intercalated into a DNA assembly immobilized on gold nanorods. The drugs were efficiently delivered to target cells and released under light irradiation, resulting in a synergism that combined phototherapy and chemotherapy for cancer treatment. This smart, photocontrollable drug release nanosystem promises precisely controlled drug release for multifunctional synergistic cancer therapy.