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Diterpenoids and Lignans from Cephalotaxus fortunei

Zhao Jin-Xin, Fan Yao-Yue, Xu Jin-Biao, Gan Li-She, Xu Cheng-Hui, Ding Jian, Yue Jian-Min
Journal of natural products 2017 v.80 no.2 pp. 356-362
Cephalotaxus, X-ray diffraction, anticarcinogenic activity, biosynthesis, branches, chemical structure, cytotoxicity, diterpenoids, inhibitory concentration 50, leaves, lignans
Five new diterpenoids including two Cephalotaxus troponoids (1 and 2), two 17-nor-cephalotane-type diterpenoids (3 and 4), and an abietane-type diterpenoid (5), two new lignans (6 and 7), and a new trisnorneoligan (8) along with eight known compounds were identified from the twigs and leaves of Cephalotaxus fortunei. The structure of 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) by X-ray crystallographic data. Compounds 3 and 4 are the first examples of 17-nor-cephalotane-type diterpenoids that are likely the biosynthesis precursors of the co-occurring troponoids (e.g., 1, 2, and 9). Compound 1 exhibited cytotoxic activities against HL-60 and A-549 cells with IC₅₀ values of 0.77 ± 0.05 and 1.129 ± 0.057 μM, respectively.