Jump to Main Content
Mutational Processes Shaping the Genome in Early Human Embryos
- Voet, Thierry, Vermeesch, Joris R.
- Cell 2017 v.168 no.5 pp. 751-753
- DNA, chromosome aberrations, genome, humans
- In-vitro-fertilized human embryos often acquire large structural and numerical chromosomal abnormalities. Liu et al. now show that multiple smaller copy number variations may also arise in in-vivo-conceived embryos. Analysis of these variations provides insight into the DNA mutational processes occurring in early embryos and the mechanisms underlying them.