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Bioactive diarylheptanoids and stilbenes from the rhizomes of Dioscorea septemloba Thunb

Author:
Zhang, Yi, Ruan, Jingya, Li, Jian, Chao, Liping, Shi, Wenzhong, Yu, Haiyang, Gao, Xiumei, Wang, Tao
Source:
Fitoterapia 2017 v.117 pp. 28-33
ISSN:
0367-326X
Subject:
Dioscorea septemloba, bioactive properties, ethanol, glucose, high performance liquid chromatography, human cell lines, myotubes, nuclear magnetic resonance spectroscopy, rhizomes, screening, silica gel, spectral analysis, stilbenes, triacylglycerols
Abstract:
The 70% ethanol extract of Dioscorea septemloba rhizomes was subjected to chromatographic columns including silica gel, ODS, D101 resin, Sephadex LH-20 and HPLC, to yield three new diarylheptanoids (1–3) and two novel stilbenes (4 and 5), together with six known ones (6–11). Their structures were elucidated on the basis of extensive 1D NMR (1H and 13C), 2D NMR (COSY, HSQC, HMBC, NOESY), IR, and MS spectroscopic data analyses. Moreover, the in vitro bioactivity screening experiment suggested that compounds 6–8 and 10 could significantly increase the glucose consumption in differentiated L6 myotubes, and that 2, 9–11 displayed triglyceride inhibitory effects in HepG2 cells.
Agid:
5641749