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Krüppel-like factor 4 (KLF4): What we currently know
- Ghaleb, Amr M., Yang, Vincent W.
- Gene 2017 v.611 pp. 27-37
- cell growth, stem cells, transcription factors, zinc
- Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been gaining a lot of attention, particularly after it was shown in 2006 as one of four factors involved in the induction of pluripotent stem cells (iPSCs). Here we review the current knowledge about the different functions and roles of KLF4 in various tissue and organ systems.