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Full-length genome analysis of vesicular stomatitis New Jersey virus strains representing the phylogenetic and geographic diversity of the virus

Author:
Pauszek, Steven J., Rodriguez, Luis L.
Source:
Archives of Virology 2012 v.157 pp. 2247
ISSN:
1432-8798
Subject:
Vesicular stomatitis New Jersey virus, amino acids, genome, genomics, pathogenesis, phylogeny, viral proteins, virus replication, viruses
Abstract:
We describe the complete genomic sequence of nine isolates of Vesicular Stomatitis New Jersey virus (VSNJV) representing six distinct phylogenetic groups and spanning the known geographic range of the virus. The total genomic length (11119-11123nt) and structure of these isolates were very similar to other Vesicular Stomatitis Viruses. There were no differences in the amino acid lengths of any of their viral proteins. As expected, the genomic termini, possessing initiation signals for viral transcription and replication, were highly conserved. These complete sequences, the first for VSNJV natural isolates, should prove useful in the design of molecular detection tests and provide the basis for future functional genomics and pathogenesis studies.
Agid:
56424
Handle:
10113/56424