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Chitosan–tripolyphosphate submicron particles as the carrier of entrapped rutin

Author:
Konecsni, K., Low, N.H., Nickerson, M.T.
Source:
Food chemistry 2012 v.134 no.4 pp. 1775-1779
ISSN:
0308-8146
Subject:
chitosan, gastric juice, health foods, particle size, rutin, small intestine
Abstract:
Chitosan (CH)–tripolyphosphate (TPP) submicron particles were formed as carriers of entrapped rutin, and the release properties characterized using simulated gastric juices and fluids of the small intestine. Particle size, charge and entrapment efficiencies were investigated as a function of the CH:TPP molar ratio (2.0:1.0–5.0:1.0). Size was found to decrease from ∼814nm for the 2.0:1:0 mass ratio to ∼528nm for the ratios between 2.5:1.0 and 4.0:1.0, and then again to ∼322nm for the 5:0:1.0 mass ratio, whereas all particles carried a positive surface charge, increasing from +21 to +59mV as the ratio increased from 2.0:1.0 to 5.0:1.0. The percent entrapment was found to rise from 3.68% to 57.6% as the ratios increased from 2.0:1:0 to 4.0:1:0, before reaching a plateau. Submicron particles (4.0:1.0 mass ratio only) were found to retain rutin in simulated gastric fluids, whereas in conditions which simulated fluids from the small intestine, only 20% of the entrapped rutin was released and 80% remained absorbed to the CH:TPP carriers. Such particles have applications for the delivery of phenolics in food and natural health products.
Agid:
564330