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Surface biofunctional drug-loaded electrospun fibrous scaffolds for comprehensive repairing hypertrophic scars

Author:
Cheng, Liying, Sun, Xiaoming, Zhao, Xin, Wang, Lan, Yu, Jia, Pan, Guoqing, Li, Bin, Yang, Huilin, Zhang, Yuguang, Cui, Wenguo
Source:
Biomaterials 2016 v.83 pp. 169-181
ISSN:
0142-9612
Subject:
adhesion, aqueous solutions, coatings, drug carriers, drug therapy, drugs, ears, in vivo studies, polyesters, rabbits, synergism, tissue repair
Abstract:
Incorporation of bioactive drugs and biofunctionalization of polyester fibrous scaffolds are essential means to improve their bio-functions and histocompatibility for regenerative medicine. However, it is still a challenge to biofunctionalize such drug carriers via traditional biochemical methods while maintaining their properties without changes in drug activity and loading ratio. Here, we demonstrated a facile approach for biofunctionalization of PLGA fibrous scaffolds with various molecules (i.e., PEG polymer, RGD peptide and bFGF growth factor for cell repellent, adhesion and proliferation, respectively) via mussel-Inspired poly(dopamine) (PDA) coating in aqueous solution. By virtue of the mild and efficient nature of this approach, the drug-loaded PLGA fibers could be easily biofunctionalized and showed negligible effects on the scaffold properties, especially drug activity and loading ratio. Further, in vivo study showed that, a ginsenoside-Rg3-loaded fibrous scaffold functionalized with bFGF growth factor could not only promote the early-stage wound healing in rabbit ear wounds (bio-signal from bFGF), but also inhibit later-stage hypertrophic scars formation (release of Rg3 drug). Therefore, the mussel-inspired method for bio-modification provides a facile and effective strategy to combine drug and bio-function in one system, thus facilitating a synergistic effect of drug-therapy and bio-signal when such biomaterial is used for regenerative medicine.
Agid:
5644714