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Properties of modified carboxymethyl cellulose and its use as bioactive compound

Basta, Altaf H., El-Saied, Houssni, El-Deftar, Mervat M., El-Henawy, Ahmed A., El-Sheikh, Hussein H., Abdel-Shakour, Essam H., Hasanin, Mohamed S.
Carbohydrate polymers 2016 v.153 pp. 641-651
Fourier transform infrared spectroscopy, Gram-negative bacteria, Gram-positive bacteria, absorption, active ingredients, anti-infective properties, bioactive compounds, bioavailability, breast neoplasms, carboxymethylcellulose, cellulose, chemical structure, cytotoxicity, fungi, inhibitory concentration 50, medicine, metabolism, minimum inhibitory concentration, nanoparticles, neoplasm cells, nitrogen content, particle size, transmission electron microscopy
The present study deals with synthesizing novel cellulose derivative, from modifying the carboxymethyl cellulose with amino phenylpropanoic acid (CMC-APP). The synthesized CMC-APP was evaluated as biological and anti-cancer active compound. The molecular structures of this active compound were built using the HyperChem program 7.5, together with conventional analysis (nitrogen content, FT-IR, and non-isothermal TGA analysis). Optimizing the CMC/APPA ratio was carried out as preliminary assessment step, via undetected antimicrobial activity measurement. The TEM study showed that, the synthesized cellulose CMC-APP derivative in the nano-scale particle size (range from 12.5 to 89.3nm). Among all the tested microorganisms and MCF-7 breast cancer cells, the synthesized nano-cellulose derivative is possible used as safety medicine for microbial infections and cancers. The minimal inhibitory concentration (MIC) for Gram-positive bacteria, and gram-negative bacteria are 48.82μg/mL and 97μg/mL, respectively. While, the unicellular fungi and filamentous fungi are 12.2μg/mL and 97.65μg/mL, respectively. The cytotoxic index (IC50) for MCF-7 breast cancers is 50μg/mL. Moreover, the computational study of ADMET (absorption, distribution, metabolism, elimination and toxic) properties, of the molecules showed that, this investigated nano-compound is good oral bioavailability.