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Facile approach to prepare drug-loading film from hemicelluloses and chitosan

Guan, Ying, Qi, Xian-Ming, Chen, Ge-Gu, Peng, Feng, Sun, Run-Cang
Carbohydrate polymers 2016 v.153 pp. 542-548
biocompatibility, cell viability, chitosan, ciprofloxacin, crosslinking, drugs, epichlorohydrins, hemicellulose, polymers, roughness, scanning electron microscopes, scanning electron microscopy, tensile strength
This study introduces a facile and green route to fabricate film from bio-based polymers. The film has been prepared by the cross-linking reaction of quaternized hemicelluloses (QH) and chitosan (CHO) with epichlorohydrin (ECH) as crosslinker. It exhibits an excellently mechanical performance as a result of its high tensile strength (up to 37MPa). Importantly, the roughness of film was 2–5nm in the area of 400nm, and smooth surface with pores were presented on the film based on the results of scanning electron microscope (SEM) and atomic force microscope (AFM). Ciprofloxacin was utilized as a mode compound to investigate the loading behavior of the film, and the highest loading concentration was about 18%. The drug release was about 20% in film1 in comparison to only 15% in film3 within 48h. Furthermore, the results of a 293T cell viability assay indicated its good biocompatibility and non-toxicity.