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Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum

Author:
Gao, Fei, Yao, Yuan-Cheng, Cai, Sheng-Bao, Zhao, Tian-Rui, Yang, Xiao-Yan, Fan, Jian, Li, Xiao-Nian, Cao, Jian-Xin, Cheng, Gui-Guang
Source:
Fitoterapia 2017 v.118 pp. 107-111
ISSN:
0367-326X
Subject:
chemical structure, concanavalin A, dexamethasone, glycosides, immunosuppression, leaves, mice, nuclear magnetic resonance spectroscopy, spectral analysis, splenocytes
Abstract:
Phytochemical investigation on the leaves of Epigynum auritum led to the isolation of three novel C21 pregnane glycosides, epigynosides, E–G (1–3), together with two known pregnane glycosides, epigynosides A (4) and C (5). Their structures were elucidated based on extensive spectroscopic data (MS, IR, 1D and 2D NMR) analysis, as well as comparison with the reported data. The immunological activities of the new compounds was evaluated against concanavalin A (Con A)-stimulated proliferation of mice splenocyte in vitro. Compounds 1–3 displayed significant immunosuppressive activities, close to the efficacy of the positive control (dexamethasone) at the concentration of 50μM.
Agid:
5646177