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Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata

Khajuria, Anamika, Gupta, Amit, Suden, Pankaj, Singh, Surjeet, Malik, Fayaz, Singh, Jaswant, Gupta, B.D., Suri, K.A., Srinivas, V.K., Ella, Krishna, Qazi, G.N.
Phytotherapy research 2008 v.22 no.3 pp. 340-348
Boswellia serrata, T-lymphocytes, antibodies, biopolymers, complement, delayed hypersensitivity, dose response, immunoglobulin G, immunoglobulin M, lymphocyte proliferation, macrophage activation, mechanism of action, mice, nitrites, oral administration, perfluorocarbons
Oral administration of BOS 2000 (1-10 mg/kg) elicited a dose related increase in the delayed hypersensitivity reaction (early 24 h and delayed 48 h) in mice. It also stimulated the IgM and IgG titre expressed in the form of plaques (PFC) and complement fixing antibody titre. The concentration of cytokines (IL-4, IFN-γ and TNF-α) in serum with respect to T cell interactions, i.e. (CD4/CD8) and the proliferation of lymphocytes were significantly increased at 10 mg/kg compared with the control. The results in these studies demonstrated the immunostimulatory effect of BOS 2000 in a dose-dependent manner with respect to the macrophage activation possibly expressing the phagocytosis and nitrite production by the enhancement of TNF-α and IFN-γ production as a mode of action.