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Metabolic engineering for the microbial production of marine bioactive compounds

Author:
Mao, Xiangzhao, Liu, Zhen, Sun, Jianan, Lee, Sang Yup
Source:
Biotechnology advances 2017 v.35 no.8 pp. 1004-1021
ISSN:
0734-9750
Subject:
bioactive compounds, drugs, metabolic engineering, nutritive value, omega-3 fatty acids, synthesis, terpenoids
Abstract:
Many marine bioactive compounds have medicinal and nutritional values. These bioactive compounds have been prepared using solvent-based extraction from marine bio-resources or chemical synthesis, which are costly, inefficient with low yields, and environmentally unfriendly. Recent advances in metabolic engineering allowed to some extent more efficient production of these compounds, showing promises to meet the increasing demand of marine natural bioactive compounds. In this paper, we review the strategies and statuses of metabolic engineering applied to microbial production of marine natural bioactive compounds including terpenoids and their derivatives, omega-3 polyunsaturated fatty acids, and marine natural drugs, and provide perspectives.
Agid:
5646604