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Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against H2O2-induced myocardial cell injury

Author:
LI, Shan-Shan, LIU, Yan-Li, XU, Qiong-Ming, MAO, Chen-Mei, YANG, Shi-Lin
Source:
Chinese journal of natural medicines 2017 v.15 no.2 pp. 115-120
ISSN:
1875-5364
Subject:
2,2-diphenyl-1-picrylhydrazyl, Ilex cornuta, Oriental traditional medicine, aerial parts, antioxidant activity, cardiomyocytes, chemical reactions, electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopy, protective effect, spectral analysis, triterpenoids
Abstract:
In the present study, three new triterpenoids, 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-α-L-arabinopyranoside (1), 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (2), and urs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (3), and a known triterpenoid, 3β-hydroxy-urs-2, 18-dien-28-oic acid (4, randialic acid B), were isolated from the aerial parts of Ilex cornuta. Their structures were identified by the spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR) and chemical reactions. Compound 4 showed significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury. Compounds 1–4 did not show any significant DPPH radical scavenging activity.
Agid:
5647851