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Hydrophobic kenaf nanocrystalline cellulose for the binding of curcumin

Zainuddin, Norhidayu, Ahmad, Ishak, Kargarzadeh, Hanieh, Ramli, Suria
Carbohydrate polymers 2017 v.163 pp. 261-269
Fourier transform infrared spectroscopy, X-ray diffraction, biodegradability, cationic surfactants, cellulose, cetyltrimethylammonium bromide, curcumin, drugs, hydrophobicity, kenaf, lignocellulose, nanocrystals, nanoparticles, surface area, transmission electron microscopy
Nanocrystalline cellulose (NCC) extracted from lignocellulosic materials has been actively investigated as a drug delivery excipients due to its large surface area, high aspect ratio, and biodegradability. In this study, the hydrophobically modified NCC was used as a drug delivery excipient of hydrophobic drug curcumin. The modification of NCC with a cationic surfactant, cetyl trimethylammonium bromide (CTAB) was used to modulate the loading of hydrophobic drugs that would not normally bind to NCC. The FTIR, Elemental analysis, XRD, TGA, and TEM were used to confirm the modification of NCC with CTAB. The effect of concentration of CTAB on the binding efficiency of hydrophobic drug curcumin was investigated. The amounts of curcumin bound onto the CTAB–NCC nanoparticles were analyzed by UV–vis Spectrophotometric. The result showed that the modified CTAB–NCC bound a significant amount of curcumin, in a range from 80% to 96% curcumin added. Nevertheless, at higher concentration of CTAB resulted in lower binding efficiency.