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Effect of the A-Type Linkage on the Pharmacokinetics and Intestinal Metabolism of Litchi Pericarp Oligomeric Procyanidins

Author:
Li, Shuyi, Liu, Yang, Liu, Gang, He, Jingren, Qin, Xinguang, Yang, Haochen, Hu, Zhongze, Lamikanra, Olusola
Source:
Journal of agricultural and food chemistry 2017 v.65 no.9 pp. 1893-1899
ISSN:
1520-5118
Subject:
Litchi, absorption, bioavailability, biochemical pathways, gastrointestinal system, ingestion, metabolites, pericarp, pharmacokinetics, polymerization, procyanidins, quantitative structure-activity relationships, rats, shikimic acid
Abstract:
The bioavailability of A-type procyanidins in vivo has been rarely investigated; as such, this study discusses the effect of A-type linkage and degree of polymerization on the metabolism of procyanidins extracted from litchi pericarp (LPOPC). Sprague–Dawley rats were gavaged with (−)-epicatechin (EC) and LPOPC and sacrificed at different time points after ingestion. A-type linkage procyanidin oligomers inhibited the absorption of EC. Analysis of urinary contents from rats administered with EC, A-type procyanidin dimer (A-2), and A-type procyanidin trimer (A-3) showed distinct native and metabolite profiles for each rat. Rats fed with A-2 and A-3 presented significantly higher levels of shikimic acid and less amount of m(p)-coumaric acid metabolites in vivo and provide insight into the quantitative structure–activity relationship of procyanidin oligomers during metabolism, indicating that procyanidins with A-type linkage could induce an altered metabolic pathway of oligomers in the gastrointestinal system.
Agid:
5653852