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Effect of the A-Type Linkage on the Pharmacokinetics and Intestinal Metabolism of Litchi Pericarp Oligomeric Procyanidins

Li, Shuyi, Liu, Yang, Liu, Gang, He, Jingren, Qin, Xinguang, Yang, Haochen, Hu, Zhongze, Lamikanra, Olusola
Journal of agricultural and food chemistry 2017 v.65 no.9 pp. 1893-1899
Litchi, absorption, bioavailability, biochemical pathways, gastrointestinal system, ingestion, metabolites, pericarp, pharmacokinetics, polymerization, procyanidins, quantitative structure-activity relationships, rats, shikimic acid
The bioavailability of A-type procyanidins in vivo has been rarely investigated; as such, this study discusses the effect of A-type linkage and degree of polymerization on the metabolism of procyanidins extracted from litchi pericarp (LPOPC). Sprague–Dawley rats were gavaged with (−)-epicatechin (EC) and LPOPC and sacrificed at different time points after ingestion. A-type linkage procyanidin oligomers inhibited the absorption of EC. Analysis of urinary contents from rats administered with EC, A-type procyanidin dimer (A-2), and A-type procyanidin trimer (A-3) showed distinct native and metabolite profiles for each rat. Rats fed with A-2 and A-3 presented significantly higher levels of shikimic acid and less amount of m(p)-coumaric acid metabolites in vivo and provide insight into the quantitative structure–activity relationship of procyanidin oligomers during metabolism, indicating that procyanidins with A-type linkage could induce an altered metabolic pathway of oligomers in the gastrointestinal system.