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Plasma-derived exosomes contribute to inflammation via the TLR9-NF-κB pathway in chronic heart failure patients
- Ye, Wei, Tang, Xiaojun, Yang, Zhengquan, Liu, Chu, Zhang, Xin, Jin, Jing, Lyu, Jianxin
- Molecular Immunology 2017 v.87 pp. 114-121
- RNA, Toll-like receptor 9, chloroquine, exosomes, heart failure, inflammation, mitochondrial DNA, patients
- Exosomes are small vesicles that contain proteins, DNA and RNA, and play an important role in inflammation; however, the underlying mechanism remains unclear. In the present study, we found increased plasma-derived exosomes in chronic heart failure patients compared with healthy controls. Further, our data demonstrated that plasma-derived exosomes carried mtDNA, and triggered an inflammatory response via the TLR9-NF-κB pathway, as well, the inflammatory effect was closely related to exosomal mtDNA copy number. However, the effect could be blocked by chloroquine (CQ), a TLR9 inhibitor. These findings reveal a new mechanism of exosome-induced inflammation, and provide a new perspective for intervention and treatment of inflammation-related diseases, such as chronic heart failure.