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Three new coumarin glycosides from the stems of Hydrangea paniculata

Author:
Ma, Jie, Li, Chuang-Jun, Yang, Jing-Zhi, Li, Yan, Bao, Xiu-Qi, Chen, Nai-Hong, Zhang, Dong-Ming
Source:
Journal of Asian natural products research 2017 v.19 no.4 pp. 320-326
ISSN:
1477-2213
Subject:
Hydrangea paniculata, blood serum, coumarin, glycosides, hepatoprotective effect, mice, neuroglia, neuroprotective effect, nitric oxide, spectral analysis, stems, toxicity
Abstract:
Three new coumarin glycosides (1-3), together with three known compounds (4-6), have been obtained from the stems of Hydrangea paniculata Sieb. Their structures were elucidated based on spectroscopic data and chemical evidence. In addition, compounds 1-3 were screened for their neuroprotective effects against serum deprivation-induced PC12 cell damage, hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line, but they were inactive.
Agid:
5661923