Jump to Main Content
Base-Controlled Reaction of α,β-Unsaturated Trifluoromethyl Ketone and Dialkyl Phosphite
- Zhang, Fan, Jiang, Min, Liu, Jin-Tao
- Tetrahedron letters 2017
- chemical reactions, chemical structure, ketones, phosphates, phosphonates
- Base-controlled selective reactions of α,β-unsaturated trifluoromethyl ketones with dialkyl phosphites were achieved. In the presence of DABCO, the Pudovik reaction took place readily to give the corresponding α-hydroxy phosphonates in high yields under mild conditions. While using DBU as base, the Phospha-Brook rearrangement of α-hydroxy phosphonates formed in the reaction occurred to afford phosphates as final products.