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Identification of Atypical Scrapie in Canadian Sheep
- Mitchell, Gordon B., O'Rourke, Katherine I., Harrington, Noel P., Soutyrine, Andrei, Simmons, Marion M., Dudas, Sandor, Zhuang, Dongyue, Laude, Hubert, Balachandran, Aru
- disease incidence, Canada, diagnostic techniques, disease surveillance, risk assessment, disease prevalence, geographical distribution, disease detection, epidemiological studies, emerging diseases, pathotypes, strains, scrapie, sheep, encephalopathy, histopathology
- Scrapie, a transmissible spongiform encephalopathy of sheep and goats, exists in most small ruminant-producing countries of the world. A novel form of this disease was recently recognized and is known by various names, including Nor98, Nor98-like, and atypical scrapie. Differing from classic scrapie in epidemiology, histopathology, and biochemical characteristics, atypical scrapie cases have been identified throughout Europe and in the United States. Enhanced scrapie surveillance efforts recently identified 3 cases of atypical scrapie in Canada.