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Pro(moting) the Turnover of Gluconeogenic Enzymes by a New Branch of the N-end Rule Pathway

Author:
Dougan, David A.
Source:
Trends in biochemical sciences 2017 v.42 no.5 pp. 330-332
ISSN:
0968-0004
Subject:
enzymes, gluconeogenesis, protein degradation
Abstract:
The N-end rule pathway is a set of protein degradation systems that link the in vivo stability of a protein to its N-terminal residue. A recent paper from Alexander Varshavsky’s laboratory [1] identifies a new branch of the N-end rule pathway that specifically recognizes the N-terminal Pro residue of key gluconeogenesis enzymes.
Agid:
5665344