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Pro(moting) the Turnover of Gluconeogenic Enzymes by a New Branch of the N-end Rule Pathway
- Dougan, David A.
- Trends in biochemical sciences 2017 v.42 no.5 pp. 330-332
- enzymes, gluconeogenesis, protein degradation
- The N-end rule pathway is a set of protein degradation systems that link the in vivo stability of a protein to its N-terminal residue. A recent paper from Alexander Varshavsky’s laboratory  identifies a new branch of the N-end rule pathway that specifically recognizes the N-terminal Pro residue of key gluconeogenesis enzymes.