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Anti-obesity effect and protection of liver-kidney functions by Codium fragile sulphated polysaccharide on high fat diet induced obese rats

Kolsi, Rihab Ben Abdallah, Jardak, Neila, Hajkacem, Faten, Chaaben, Rim, jribi, Imed, Feki, Abdelfattah El, Rebai, Tarak, Jamoussi, Kamel, Fki, Lotfi, Belghith, Hafedh, Belghith, Karima
International journal of biological macromolecules 2017 v.102 pp. 119-129
Codium fragile, antioxidants, blood serum, carboxylic ester hydrolases, catalase, enzyme activity, glutathione peroxidase, high density lipoprotein cholesterol, high fat diet, hyperlipidemia, kidneys, lipemic effect, liver, low density lipoprotein cholesterol, obesity, oxidative stress, polysaccharides, protective effect, rats, superoxide dismutase, thiobarbituric acid-reactive substances, triacylglycerols
The present study investigates the hypolipidemic effects of sulphated polysaccharide obtained from Codium fragile (CFSP) in induced obese rats (HFD).The results showed an increase in body weight of HFD rats by 21.56% as compared to control normal rats. Moreover, serum lipase activity underwent an increase which led to an increase in the levels of total cholesterol (T-Ch), triglycerides (TG) and low density lipoprotein cholesterol (LDL-Ch) in serum associeted with a decrease in the level of high density lipoprotein cholesterol (HDL-Ch) in untreated HFD rats. This diet has disrupted the antioxidant status by decreasing the activities of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX)) and subsequently an increase in thiobarbituric acid reactive substances (TBARS) level in liver and kidney of obese rats. All these disturbances are significantly corrected by CFSP administration with no fatty deposits in the liver and a protective effect against renal histological alteration. This confirms the important role of this polysaccharide in the fight against oxidative stress and the prevention of hyperlipidemia.