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New ursane-type triterpenoids from Clerodendranthus spicatus
- Luo, Yong, Cheng, Li-Zhi, Luo, Qi, Yan, Yong-Ming, Wang, Shu-Mei, Sun, Qin, Cheng, Yong-Xian
- Fitoterapia 2017 v.119 pp. 69-74
- Orthosiphon aristatus, X-ray diffraction, aerial parts, anticarcinogenic activity, cell proliferation, chemical structure, fibroblasts, humans, kidneys, neoplasm cells, neoplasms, rats, spectroscopy, transforming growth factor beta 1, triterpenoids
- Five new ursane-type triterpenoids, spicatusoids A–E (1, 3–6), and three known ones (2, 7, and 8), and a known oleanane-type triterpenoid (9) were isolated from the aerial parts of Clerodendranthus spicatus. Their structures were elucidated by spectroscopic methods. In particular, the structure of 3 including its absolute configuration was confirmed by single-crystal X-ray diffraction analysis. Cell viability of all the compounds against rat kidney fibroblast cells (NRK-49F) with or without TGF-β1 induction and human cancer cells (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) was examined by using MTT or MST assays. It was found that, with exception of 1, all the tested compounds could inhibit cell proliferation in TGF-β1 induced NRK-49F cells with compounds 2 being most active.