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Neolignans and serratane triterpenoids with inhibitory effects on xanthine oxidase from Palhinhaea cernua

Author:
Li, Jing, Xu, Ping-Sheng, Tan, Lei-Hong, Zou, Zhen-Xing, Wang, Yi-Kun, Long, Hong-Ping, Zhou, Gan, Li, Guang, Xu, Kang-Ping, Tan, Gui-Shan
Source:
Fitoterapia 2017 v.119 pp. 45-50
ISSN:
0367-326X
Subject:
circular dichroism spectroscopy, ethanol, inhibitory concentration 50, ketones, lignans, nuclear magnetic resonance spectroscopy, triterpenoids, xanthine oxidase
Abstract:
Three new neolignans, lycocernuasides B-D (1–3), three new serratane triterpenoids, lycernuic ketones D (8) and E (9), and lycernuic A (10), together with six known compounds, were isolated from the 75% aqueous EtOH extract of Palhinhaea cernua. Their structures and absolute configurations were established primarily by NMR, HRESIMS and circular dichroism (CD). All compounds were evaluated the inhibitory activities of xanthine oxidase. Compounds 1–3 displayed moderate inhibitory effects on xanthine oxidase with IC50 values of 30.36μM, 42.65μM and 35.33μM, respectively.
Agid:
5667467