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Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling
- Ramkumarie Baliram, Li Sun, Jay Cao, Jianhua Li, Rauf Latif, Amanda K. Huber, Tony Yuen, Harry C. Blair, Mone Zaidi, Terry F. Davies
- Journal of clinical investigation 2012 v.122 no.10 pp. 3737-3741
- bone resorption, hyperthyroidism, mice, osteopenia, osteoporosis, phenotype, skeleton, thyroid hormones, thyrotropin
- The osteoporosis associated with human hyperthyroidism has traditionally been attributed to elevated thyroid hormone levels. There is evidence, however, that thyroid-stimulating hormone (TSH), which is low in most hyperthyroid states, directly affects the skeleton. Importantly, Tshr-knockout mice are osteopenic. In order to determine whether low TSH levels contribute to bone loss in hyperthyroidism, we compared the skeletal phenotypes of wild-type and Tshr-knockout mice that were rendered hyperthyroid. We found that hyperthyroid mice lacking TSHR had greater bone loss and resorption than hyperthyroid wild-type mice, thereby demonstrating that the absence of TSH signaling contributes to bone loss. Further, we identified a TSH-like factor that may confer osteoprotection. These studies suggest that therapeutic suppression of TSH to very low levels may contribute to bone loss in people.