U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.


Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Main content area

Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling

Ramkumarie Baliram, Li Sun, Jay Cao, Jianhua Li, Rauf Latif, Amanda K. Huber, Tony Yuen, Harry C. Blair, Mone Zaidi, Terry F. Davies
Journal of clinical investigation 2012 v.122 no.10 pp. 3737-3741
bone resorption, hyperthyroidism, mice, osteopenia, osteoporosis, phenotype, skeleton, thyroid hormones, thyrotropin
The osteoporosis associated with human hyperthyroidism has traditionally been attributed to elevated thyroid hormone levels. There is evidence, however, that thyroid-stimulating hormone (TSH), which is low in most hyperthyroid states, directly affects the skeleton. Importantly, Tshr-knockout mice are osteopenic. In order to determine whether low TSH levels contribute to bone loss in hyperthyroidism, we compared the skeletal phenotypes of wild-type and Tshr-knockout mice that were rendered hyperthyroid. We found that hyperthyroid mice lacking TSHR had greater bone loss and resorption than hyperthyroid wild-type mice, thereby demonstrating that the absence of TSH signaling contributes to bone loss. Further, we identified a TSH-like factor that may confer osteoprotection. These studies suggest that therapeutic suppression of TSH to very low levels may contribute to bone loss in people.