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Antiageing activities of water-soluble chitosan from Clanis bilineata larvae

Author:
Wu, Shengjun, Lu, Mingsheng, Wang, Shujun
Source:
International journal of biological macromolecules 2017
ISSN:
0141-8130
Subject:
animal models, antioxidant activity, antioxidants, chitosan, dietary supplements, dose response, glutathione peroxidase, humans, hydroxyl radicals, larvae, malondialdehyde, mice, superoxide anion, superoxide dismutase
Abstract:
Water extracts were prepared using water-soluble chitosan from Clanis bilineata larva skin. This study also investigated antioxidant and antiageing activities of water-soluble chitosan. Water-soluble chitosan of Clanis bilineata larva skin (CBLSWSC) showed considerable scavenging activities on superoxide anion and hydroxyl radicals and reducing capacity. Different doses of CBLSWSC were intragastrically administered on a d-galactose-induced-aged mouse model over a period of six weeks. Intragastric CBLSWSC administration significantly increased activities of superoxide dismutase and glutathione peroxidase and inhibited formation of malondialdehyde in brains and sera of mice in a dose-dependent manner. Results suggest that CBLSWSC exhibits high antioxidant activity and can be developed as potential dietary supplement to retard ageing in humans.
Agid:
5671130