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Fatal community-acquired ribotype 002 Clostridium difficile bacteremia

Author:
Dauby, Nicolas, Libois, Agnès, Van Broeck, Johan, Delmée, Michel, Vandenberg, Olivier, Martiny, Delphine
Source:
Anaerobe 2017 v.44 pp. 1-2
ISSN:
1075-9964
Subject:
Clostridium difficile, bacteremia, blood, colitis, embolism, health services, hospitals, hunger, mortality, patients, pneumonia, ribotypes, tandem repeat sequences, vancomycin
Abstract:
Extra-colonic infections, and especially bacteremia, are infrequent manifestations of Clostridium difficile infection. C. difficile bacteremia is generally health-care associated and polymicrobial. We report the case of a patient on hunger strike that presented a C. difficile colitis and mono-microbial bacteremia on its admission to the hospital. Multilocus variable number tandem repeat analysis of stool and blood isolates indicated clonality. The strain was characterized as a ribotype 002, an emerging ribotype previously associated with high fatality rate. The patient received treatment by intra-venous amoxicillin-clavulanate and oral vancomycin but eventually died on the seventh day of admission with concomitant pneumonia and pulmonary embolism.
Agid:
5673367