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Neolignan and monoterpene glycoside from the seeds of Pharbitis nil

Seoung Rak Lee, Eunjung Moon, Ki Hyun Kim
Phytochemistry letters 2017 v.20 pp. 98-101
Ipomoea nil, anti-inflammatory activity, chemical structure, cytotoxicity, ethanol, glycosides, inhibitory concentration 50, lignans, lipopolysaccharides, mice, monoterpenoids, nitric oxide, nuclear magnetic resonance spectroscopy, seeds, spectral analysis
Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R,8S-threo-dihydroxydehydrodiconiferyl alcohol (1), and a new monoterpene glycoside, (3Z,7S)-7-hydroxy-3,7-dimethyl-3,8-octadienyl-β-d-glucopyranoside (2), together with a known compound, ethyl α-l-arabinofuranoside (3). The chemical structures of these compounds were unambiguously determined using physical data, HR-ESI–MS and spectroscopic evidence, including 1D and 2D NMR experiments. The anti-inflammatory activities of the isolates were evaluated by estimating the inhibition of nitric oxide (NO) production. Compounds 1 and 2 reduced NO levels in lipopolysaccharide (LPS)-stimulated murine microglial BV-2 cells. In addition, compound 2 showed weak cytotoxicity against the HCT-15 cell line with an IC50 value of 28.6μM.