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Live-Cell Nanoscopy in Antiadhesion Therapy

Author:
Geoghegan, Joan A., Foster, Timothy J., Speziale, Pietro, Dufrêne, Yves F.
Source:
Trends in microbiology 2017 v.25 no.7 pp. 512-514
ISSN:
0966-842X
Subject:
Staphylococcus aureus, adhesion, glycoconjugates, monoclonal antibodies, pathogens, synthetic peptides, technology, therapeutics, uropathogenic Escherichia coli
Abstract:
Live-cell nanoscopy has contributed significantly to assessing the inhibition of adhesion of uropathogenic Escherichia coli and Staphylococcus aureus by glycoconjugates and monoclonal antibodies, respectively, and of S. aureus surface attachment and cell–cell association by a synthetic peptide. This new technology shows promise for the development of antiadhesion therapies against bacterial pathogens.
Agid:
5677057