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α-Glucosidase inhibitors from the stem of Mangifera reba

Truc T.T. Duong, Truong N.V. Do, Hai X. Nguyen, Tho H. Le, Phu H. Dang, Nhan T. Nguyen, Tuyen N.T. Nguyen, Thao D. Nguyen, Mai T.T. Nguyen
Tetrahedron letters 2017 pp. -
Mangifera, acarbose, alpha-glucosidase, biochemical pathways, chemical reactions, chemical structure, inhibitory concentration 50, lignans, nuclear magnetic resonance spectroscopy, spectral analysis
Two new neolignans, named rebaneolignan A (1) and B (2), were isolated from the stem of Mangifera reba (Anacardiaceae), together with six known compounds (3–8). Their structures were elucidated on the basis of NMR spectroscopic analysis and the absolute configurations of 1 and 2 were determined by NOESY and CD data. All isolated compounds were found to possess more potent inhibitory activity, with IC50 values ranging from 28.5 to 162.8µM, than the positive control acarbose (IC50, 214.5µM). Plausible biosynthetic pathways for the formation of 1 and 2 were proposed based on the oxidative β-5′ coupling reactions.