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Protein based therapeutic delivery agents: Contemporary developments and challenges
- Yin, Liming, Yuvienco, Carlo, Montclare, Jin Kim
- Biomaterials 2017 v.134 pp. 91-116
- bioavailability, biocompatibility, biodegradability, biopolymers, gene therapy, genes, peptides, proteins, toxicity
- As unique biopolymers, proteins can be employed for therapeutic delivery. They bear important features such as bioavailability, biocompatibility, and biodegradability with low toxicity serving as a platform for delivery of various small molecule therapeutics, gene therapies, protein biologics and cells. Depending on size and characteristic of the therapeutic, a variety of natural and engineered proteins or peptides have been developed. This, coupled to recent advances in synthetic and chemical biology, has led to the creation of tailor-made protein materials for delivery. This review highlights strategies employing proteins to facilitate the delivery of therapeutic matter, addressing the challenges for small molecule, gene, protein and cell transport.