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Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives

Author:
He, Dan, Wang, Menglei, Zhao, Siyu, Shu, Yisong, Zeng, Honglian, Xiao, Cheng, Lu, Cheng, Liu, Yuanyan
Source:
Fitoterapia 2017 v.119 pp. 136-149
ISSN:
0367-326X
Subject:
anti-inflammatory activity, anticarcinogenic activity, anticonvulsants, antifungal properties, heterocyclic nitrogen compounds, structure-activity relationships
Abstract:
Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted increasing interest because of their broad spectrum of biological functions. This review describes three types of natural quinazolinones and their synthesized derivatives and summarizes their various pharmacological activities, including antifungal, anti-tumor, anti-malaria, anticonvulsant, anti-microbial, anti-inflammatory and antihyperlipidemic activities. In addition, structure-activity relationships of quinazolinone derivatives are also reviewed.
Agid:
5686388