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Microfluidics as a strategic player to decipher single-cell omics?
- Caen, Ouriel, Lu, Heng, Nizard, Philippe, Taly, Valérie
- Trends in biotechnology 2017
- biotechnology, cells, high-throughput nucleotide sequencing, normal distribution
- Most cell studies are performed at a population level, relying on the assumption of a normal distribution of cell’s function and fate among a population. However, technologies allowing single cell analysis have recently emerged and led to increasing evidence of cell population heterogeneity and its importance. Tremendous amounts of new data could now be uncovered to redefine our understanding of cell omics. Microfluidics has emerged as a major technological player in this new era that is gradually emerging among biology laboratories, mainly due to the single-cell high-throughput handling solutions it offers. This review assesses its use and relevance for omics analysis at the single-cell level with a specific focus on compartment-based microfluidic approaches.