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Effects on the reproductive system of young male rats of subcutaneous exposure to n-butylparaben

Author:
Garcia, Tania, Schreiber, Elga, Kumar, Vikas, Prasad, Raju, Sirvent, Juan J., Domingo, Jose L., Gómez, Mercedes
Source:
Food and chemical toxicology 2017 v.106 pp. 47-57
ISSN:
0278-6915
Subject:
body weight changes, excretion, histopathology, males, peanut oil, rats, reproductive system, sperm motility, spermatozoa, tissue weight, toxicity, toxicology, viability
Abstract:
This study was aimed at determining whether an in vivo subcutaneous exposure to n-butylparaben (n-ButP) during one complete spermatogenic cycle could be harmful to the reproductive system of young male rats. Animals were subcutaneously given 0, 150, 300 and 600 mg/kg/day of n-ButP with vehicle (peanut oil). Body and organ weights, n-ButP excretion, biochemical parameters, sperm and spermatid count, sperm motility, viability, maturity and morphology were examined. Results showed that after a completed spermatogenic cycle, although n-ButP did not induce dose-related changes in the different biochemical parameters, a significant decrease of triacylglicerides (TAG) –due to the vehicle-was found. Furthermore, no effects of n-ButP on body weight gain and relative organ weight changes were noted. Regarding sexual organs, prostate relative weight was significantly increased at the high dose of n-ButP. On the other hand, a significant increase of abnormal sperm morphology due to n-ButP exposure, accompanied by different alterations in sexual organs histopathology, was found. The current results indicate that subcutaneous exposure of n-ButP in young male rats induced toxic effects on the reproductive system, which could affect the capacity of fertilization of animals.
Agid:
5691118