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ent-Abietane and Tigliane Diterpenoids from the Roots of Euphorbia fischeriana and Their Inhibitory Effects against Mycobacterium smegmatis

Author:
Wang, Chun-Jie, Yan, Qiu-Long, Ma, Yu-Fang, Sun, Cheng-Peng, Chen, Chang-Ming, Tian, Xiang-Ge, Han, Xiu-Yan, Wang, Chao, Deng, Sa, Ma, Xiao-Chi
Source:
Journal of natural products 2017 v.80 no.5 pp. 1248-1254
ISSN:
1520-6025
Subject:
Euphorbia fischeriana, Mycobacterium smegmatis, antibacterial properties, bioassays, chemical composition, chemical structure, chromatography, diterpenoids, models, roots, spectral analysis
Abstract:
An investigation on the bioactive chemical constituents of the roots of Euphorbia fischeriana has been conducted, with 21 diterpenoids obtained using various chromatographic techniques. On the basis of spectroscopic data analysis, the new compounds were elucidated as four ent-abietane-type diterpenoids (1–4) and four tigliane-type diterpenoids (13–16). Also obtained were eight known ent-abietane (5–12) and five known tigliane (17–21) diterpenoids. The potential antituberculosis effects of these diterpenoids were evaluated using a Mycobacterium smegmatis model. The most potent compound according to the in vitro bioassay used was 17-hydroxyjolkinolide B (12) (MIC 1.5 μg/mL).
Agid:
5693700