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Design and synthesis of 28-hydroxy protopanaxadiol as a novel probe template
- Liu, Ze-Yun, Zhang, Heng-Yuan, Bi, Yi, Liu, Xian-Xuan, Lu, Jing, Zhang, Xiao-Chen, Xu, Jin-Yi, Wang, Chong-Zhi, Yuan, Chun-Su
- Natural product research 2017 v.31 no.13 pp. 1523-1528
- antineoplastic activity, electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopy, sapogenins, synthesis
- To explore the antitumour mechanism of 20(S)-protopanaxadiol (PPD) while maintaining its uncovered pharmacological active site 3-hydroxyl, 28-hydroxy protopanaxadiol (17), a small molecular probe template of PPD was first designed and synthesised based on the Baldwin’s reaction. Thus, 28-hydroxyl of 17 was built successfully as a derivatized site of molecular probe’s functional and report groups. The important intermediates and final product were confirmed by ESI-MS and nuclear magnetic resonance spectra with good yield. These studies provided a valuable basis for probe research of PPD.