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Effect of microbial siderophores on mammalian non-malignant and malignant cell lines

Author:
Gokarn, Karuna, Sarangdhar, Vishwas, Pal, RamprasadB.
Source:
BMC complementary and alternative medicine 2017 v.17 no.1 pp. 145
ISSN:
1472-6882
Subject:
alternative medicine, deferoxamine, iron, mammals, neoplasms, siderophores, viability
Abstract:
BACKGROUND: Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment. METHODS: In the present study, we have evaluated effect of three siderophores – exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay. RESULTS: These siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells. CONCLUSIONS: Based on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies.
Agid:
5698549