U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

Impact of Novel Sorghum Bran Diets on DSS-Induced Colitis

Author:
Lauren E. Ritchie, Stella S. Taddeo, Brad R. Weeks, Raymond J. Carroll, Linda Dykes, Lloyd W. Rooney, Nancy D. Turner
Source:
Nutrients 2017 v.9 no.4 pp. -
ISSN:
2072-6643
Subject:
Sorghum (Poaceae), animal experimentation, bran, cellulose, colitis, colon, dextran sulfate, diarrhea, diet, feces, gene expression regulation, homeostasis, inflammation, intestinal microorganisms, laboratory animals, males, proanthocyanidins, rats, resection, short chain fatty acids, transforming growth factor beta, transporters
Abstract:
We have demonstrated that polyphenol-rich sorghum bran diets alter fecal microbiota; however, little is known regarding their effect on colon inflammation. Our aim was to characterize the effect of sorghum bran diets on intestinal homeostasis during dextran sodium sulfate (DSS)-induced colitis. Male Sprague-Dawley rats (N = 20/diet) were provided diets containing 6% fiber from cellulose, or Black (3-deoxyanthocyanins), Sumac (condensed tannins) or Hi Tannin Black (both) sorghum bran. Colitis was induced (N = 10/diet) with three separate 48-h exposures to 3% DSS, and feces were collected. On Day 82, animals were euthanized and the colon resected. Only discrete mucosal lesions, with no diarrhea or bloody stools, were observed in DSS rats. Only bran diets upregulated proliferation and Tff3, Tgfβ and short chain fatty acids (SCFA) transporter expression after a DSS challenge. DSS did not significantly affect fecal SCFA concentrations. Bran diets alone upregulated repair mechanisms and SCFA transporter expression, which suggests these polyphenol-rich sorghum brans may suppress some consequences of colitis.
Agid:
5700706
Handle:
10113/5700706