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Synthesis of 2,3,6-trisubstituted pyridines by transition-metal free cyclization of 1,3-diynes with amino acids

Author:
Zhou, Gang, Zhao, Xiaoming, Dan, Wenyan
Source:
Tetrahedron letters 2017
ISSN:
0040-4039
Subject:
amino acids, chemical reactions, chemical structure, dimethyl sulfoxide, pyridines
Abstract:
Amino acids are firstly employed in transition-metal free heterocyclization reaction of 1,3-diynes in the presence of K3PO4 and DMSO at 120 °C. This method produces 2,3,6-trisubstituted pyridines with up to 86% yield. The -CO2H group on the amino acids is crucial for this heterocyclization reaction. The mechanism of such a heterocyclization reaction is discussed, as well
Agid:
5701580