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Exposure to benzophenones, parabens and triclosan among pregnant women in different trimesters

Author:
Zhao, Hongzhi, Huo, Wenqian, Li, Jiufeng, Ma, Xinli, Xia, Wei, Pang, Zhengji, Xie, Mingyi, Xu, Shunqing, Cai, Zongwei
Source:
The Science of the total environment 2017 v.607-608 pp. 578-585
ISSN:
0048-9697
Subject:
adverse effects, fetus, humans, maternal exposure, methylparaben, pollutants, prediction, pregnancy, pregnant women, progeny, risk, urine
Abstract:
Humans are potentially exposed to many environmental pollutants, many of which may cause adverse health effects, especially to pregnant women and their fetuses. In this study, 11 environmental pollutants from three different chemical classes, including benzophenones, parabens and triclosan were measured in 627 urine samples collected from 209 pregnant women to evaluate exposure and trends as a function of pregnancy stage. Methylparaben (MeP), ethylparaben, propylparaben (PrP), butylparaben, 2,4-dihydroxybenzophenone (BP-1), 2-hydroxy-4-methoxybenzophenone (BP-3) and 4-hydroxybenzophenone were detected in >50% samples. The concentrations of BP-1 and BP-3 (Spearman's r=0.57, p<0.01) and those of MeP and PrP (Spearman's r=0.68, p<0.01) were found to be correlated. The urinary concentrations of BP-1 and BP-3 in the first trimester were significantly higher than those in the second or third trimester (Mann-Whitney U test, p<0.05). These findings provide valuable information for improving the prediction of maternal exposure to these emerging pollutants and for assessing their potential health risks to the mother as well as the offspring.
Agid:
5701833