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Lignans from the root of Wikstroemia indica and their cytotoxic activity against PANC-1 human pancreatic cancer cells

Author:
Chang, Hang, Wang, Yuwei, Gao, Xue, Song, Zehai, Awale, Suresh, Han, Na, Liu, Zhihui, Yin, Jun
Source:
Fitoterapia 2017 v.121 pp. 31-37
ISSN:
0367-326X
Subject:
Wikstroemia indica, cytotoxicity, humans, lignans, methylene chloride, neoplasm cells, nuclear magnetic resonance spectroscopy, pancreatic neoplasms, roots, spectral analysis
Abstract:
Six new compounds, wikstronin A (1), wikstronin B (2), wikstresinol (3), acetylwikstresinol (4), bis-5′,5′-(+)-matairesinol (5), bis-5,5′-(+)-matairesinol (6), together with 20 known compounds (7–26) were isolated from the CH2Cl2 extract of roots of Wikstroemia indica. Structures of compounds 1–6 were determined by extensive NMR and CD spectroscopic analysis. In vitro preferential cytotoxicity of all the isolates was evaluated against a PANC-1 human pancreatic cell line. Compounds 8 and 12 displayed mild preferential cytotoxicity in the nutrient-deprived medium (NDM) and without causing toxicity in normal nutrient-rich conditions.
Agid:
5703103