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Encapsulation of the flavonoid quercetin with chitosan-coated nano-liposomes

Author:
Hao, Jianpeng, Guo, Bing, Yu, Shaoxuan, Zhang, Wentao, Zhang, Daohong, Wang, Jianlong, Wang, Yanru
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2017 v.85 pp. 37-44
ISSN:
0023-6438
Subject:
antioxidant activity, antioxidants, biocompatibility, chitosan, encapsulation, foods, human cell lines, hydrophobicity, nanocapsules, particle size, quercetin, storage quality
Abstract:
A facile electrostatic deposition method was proposed to encapsulate quercetin within chitosan/lecithin polymeric nanocapsules, with the aim to protect quercetin against degradation and enhance its biocompatibility. Quercetin loaded polymeric nanocapsules (Q-NPs) were characterized in terms of size, morphology, encapsulation efficiency, storage stability, anti-oxidant and anti-proliferative activities. The obtained homogeneous and spherical Q-NPs have small particle size and high encapsulation efficiency (71.14%). The storage stability and antioxidant activity was improved compared with native quercetin. MTT assay and trypan blue exclusion assay showed the inhibitory effect of Q-NPs on HepG2 cells were comparable with that of free quercetin. This novel nanocapsule may provide a new system for the protection and delivery of a range of hydrophobic chemicals in vivo and food products.
Agid:
5705438