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Manufacturing Cell Therapies Using Engineered Biomaterials

Author:
Abdeen, Amr A., Saha, Krishanu
Source:
Trends in biotechnology 2017
ISSN:
0167-7799
Subject:
biocompatible materials, cell engineering, clinical trials, genome, humans, manufacturing, phenotype
Abstract:
Emerging manufacturing processes to generate advanced regenerative cell therapies involve extensive genomic and/or epigenomic manipulation of autologous or allogeneic cells. These cell engineering processes need to be carefully controlled and standardized to maximize safety and efficacy in clinical trials. Engineered biomaterials with smart and tunable properties offer an intriguing tool to provide or deliver cues to retain stemness, direct differentiation, promote reprogramming, manipulate the genome, or select functional phenotypes. This review discusses the use of engineered biomaterials to control human cell manufacturing. Future work exploiting engineered biomaterials has the potential to generate manufacturing processes that produce standardized cells with well-defined critical quality attributes appropriate for clinical testing.
Agid:
5706157