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Self-assembled amphiphilic core-shell nanocarriers in line with the modern strategies for brain delivery

Elezaby, Reham S., Gad, Heba A., Metwally, Abdelkader A., Geneidi, Ahmed S., Awad, Gehanne A.
Journal of Controlled Release 2017 v.261 pp. 43-61
blood-brain barrier, brain, drugs, ligands, micelles, nanocarriers
Disorders of the central nervous system (CNS) represent increasing social and economic problems all over the world which makes the effective transport of drugs to the brain a crucial need. In the last decade, many strategies were introduced to deliver drugs to the brain trying to overcome the challenge of the blood brain barrier (BBB) using both invasive and non-invasive methods. Non-invasive strategy represented in the application of nanocarriers became very common. One of the most hopeful nanoscopic carriers for brain delivery is core-shell nanocarriers or polymeric micelles (PMs). They are more advantageous than other nanocarriers. They offer small size, ease of preparation, ease of sterilization and the possibility of surface modification with various ligands. Hence, the aim of this review is to discuss modern strategies for brain delivery, micelles as a successful delivery system for the brain and how micelles could be modified to act as “magic bullets” for brain delivery.