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Cytotoxic aspidofractinine alkaloids from Kopsia hainanensis
- Wang, Ying, Hang, Lei, Jiao, Li, Liu, Hui, Li, Fei
- Fitoterapia 2017
- alkaloids, cytotoxicity, ethanol, inhibitory concentration 50, leaves, neoplasm cells, nuclear magnetic resonance spectroscopy, stems
- Five new aspidofractinine-type alkaloids, kopsiahainins A–E (1–5), were isolated from a 80% EtOH extract of the leaves and stems of Kopsia hainanensis. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D-NMR, IR, UV, and HR-ESI-MS. Alkaloids 3 and 4 exhibited some cytotoxic activity against all of six tested tumor cell lines (BGC-823, HepG2, MCF-7, SGC-7901, SK-MEL-2, and SK-OV-3) with IC50 values of 7.3–9.5μM and 9.2–10.6μM, respectively.