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Discovery of single nucleotide polymorphisms in candidate genes associated with fertility and production traits in Holstein cattle

Sarah D. Cochran, John B. Cole, Daniel J. Null, Peter J. Hansen
BMC genetics 2013 v.14 no.49 pp. -
Holstein, apoptosis, conception rate, dairy bulls, dairy cows, daughters, estradiol, female fertility, gene expression regulation, genes, genetic markers, genetic merit, genotype, immune response, male fertility, milk fat yield, milk protein yield, pregnancy rate, reproductive traits, semen, single nucleotide polymorphism, somatic cell count
Background Identification of single nucleotide polymorphisms (SNPs) for specific genes involved in reproduction might improve reliability of genomic estimates for these low-heritability traits. Semen from 550 Holstein bulls of high (? 1.7; n?=?288) or low (? ?2; n?=?262) daughter pregnancy rate (DPR) was genotyped for 434 candidate SNPs using the Sequenom MassARRAY(R) system. Three types of SNPs were evaluated: SNPs previously reported to be associated with reproductive traits or physically close to genetic markers for reproduction, SNPs in genes that are well known to be involved in reproductive processes, and SNPs in genes that are differentially expressed between physiological conditions in a variety of tissues associated in reproductive function. Eleven reproduction and production traits were analyzed. Results A total of 40 SNPs were associated (P?